November 2006
p53 degradation: N-acetylglucosamine strikes back
Modification of p53 by O-linked N-acetylglucosamine (GlcNAc) at Ser 149 inhibits phosphorylation at Thr 155, thereby preventing ubiquitination and proteosomal degradation.
Original research paper: Nature Cell Biology 8, 1074-1083 (2006)
doi:10.1038/ncb1470Neuronal activity: Polysialic acid as a modulator of neurotransmission
The polysaccharide polysialic acid (PSA) interacts specifically with the NR2B subunit of the N-methyl-D-aspartate-subtype of glutamate receptors (NMDARs) and diminishes glutamate-induced cytotoxicity.
Original research paper: J. Biol. Chem. 281, 34859-34869 (2006)
doi:10.1074/jbc.M602568200