July 2007

• Intracellular glycosylation: A QUICtag for GlcNAc

  A new combination of tagging, isotope labeling and peptide fragmentation by electron transfer enables the analysis of N–acetylglucosamine (GlcNAc) glycosylation dynamics and identification of GlcNAcylated protein sites.

  Original research paper: Nat. Chem. Biol. 3, 339-348 (2007)
  doi:10.1038/nchembio881

• DC-SIGN signaling: Good receptor, bad receptor

  The DC-SIGN receptor can promote two distinct cellular responses when activated: increasing NF-B activity through acetylation by stimulating the Ras/Raf-1 pathway, and Rho GTPase activation through binding to the Rho GEF LARG.

  Original research paper: Immunity 26, 605-616 (2007)
  doi:10.1016/j.immuni.2007.03.012