August 2007

• Lymphocytes: T helpers' sugar signature

  The varying cell surface glycan composition of T_H1, T_H-17 and T_H2 T helper cells controls the different cell fates that occur upon lectin binding.

  Original research paper: Nature Immunology 8, 825-834 (2007)
  doi:10.1038/ni1482

• N-glycosylation: Less tumors, more T cells

  Ablation of N-acetylglucosamine transferase 5 (Mgat5) leads to diminished growth of mouse fibroblasts and pluripotent cells but to enhanced T-cell proliferation.

  Original research paper: Cell 129, 123-134 (2007)
  doi:10.1016/j.cell.2007.01.049