September 2007
Inflammation: Neutrophil integrins switched on by selectins
The interaction between P-selectin and P-selectin glycoprotein ligand-1 on neutrophils leads to integrin transactivation via phosphatidylinositol-3-OH kinase signaling and neutrophil accumulation at sites of inflammation.
Original research paper: Nature Immunology 8, 882-892 (2007)
doi:10.1038/ni1491Autommunity: Macrophages hunting mannose singles
Macrophage accumulation in the kidneys of systemic lupus erythematosus patients is caused by the presence of proteins possessing simplified N-glycan structures.
Original research paper: Immunity 27, 308-320 (2007)
doi:10.1016/j.immuni.2007.06.008