May 2008
Cancer cell MUC1: At the tumor stem
The transmembrane mucin MUC1 occurs in a stem cell subpopulation of the breast cancer cell line MCF-7, and can be targeted in an immunotherapeutic approach by chimeric antigen T-cell receptors.
Original research paper: Cancer Research 68, 2419-2426 (2008)
doi:10.1158/0008-5472.CAN-07-2249Angiogenesis: A small candy for the tumor
The fucosylated histo-blood group glycans H2 and Lewis Y are expressed on subgroups of human endothelial cells and promote migration and tumor angiogenesis.
Original research paper: Journal of Cellular Physiology 215, 27-36 (2008)
doi:10.1002/jcp.21285