July 2008

• Alzheimer disease and protein turnover: A GlcNAc trick

  Protein turnover may be regulated by O-glycosylation with N-acetylglucosamine (GlcNAc), and an O-GlcNAcase-inhibitor complex and an O-GlcNAc transferase homolog reveal surprising new structural features.

  Original research paper: FASEB Journal, (23 April 2008)
  doi:10.1096/fj.07-102509

• Neutrophil trafficking: CXCR2's icing on the cake

  Sialylation of the neutrophil CXCR2 receptor is required for its interaction with the chemokines CXCL8 and CXCL1, which induces neutrophil arrest and prepares neutrophil extravasation.

  Original research paper: Journal of Experimental Medicine 205, 1435-1446 (2008)
  doi:10.1084/jem.20070846