January 2009
Bacterial infection: Receptor glycans form a crucial interface
The secreted staphylococcal superantigen-like protein SSL5 binds to N-glycans on neutrophil G protein coupled receptors (GPCRs), thus blocking neutrophil activation and aiding the immune evasion of Staphylococcus aureus.
Original research paper: Blood (21 October 2008)
doi:10.1182/blood-2008-04-153882Tissue development: Cleaving an acidic sugar promotes differentiation
Silencing glycolipid desialylation on muscle progenitor cells abrogates differentiation into muscle fibers and promotes apoptosis.
Original research paper: J. Biol. Chem. (22 October 2008)
doi:10.1074/jbc.M805755200