January 2009

• Epileptic seizures: Sugars-coated leukocytes get roped in

  Inhibition of P-selectin glycoprotein ligand-1 (PSGL-1) and other leukocyte adhesion molecules impairs leukocyte-endothelial cell interactions, dampens blood-brain barrier leakage and prevents seizures in mice.

  Functional Glycomics Gateway (2009)
  doi:10.1038/fg.2009.3

• Neurons: Sugar-free cells cannot compete

  Activation of the immunoglobulin superfamily member L1 triggers neuron glycosylation and promotes neurite outgrowth, migration and survival.

  Functional Glycomics Gateway (2009)
  doi:10.1038/fg.2009.4