February 2009

• Protein folding: Sweet signals for degradation

  The Man₇GlcNAc₂ sugar is produced by the Htm1p protein and functions as a flag for misfolded glycoproteins, which are recognised by the Yos9p lectin and targeted for degradation.

  Original research paper: J Cell Biol. 184, 159-172 (2008)
  doi:10.1083/jcb.200809198

• Adaptive immunity: Rel-ative contributions of Raf and Syk

  Dectin-1 signals through Syk and Raf-1 to regulate activation of the noncanonical NF-B pathway and T_H cell differentiation in response to fungal infection.

  Original research paper: Nat. Immunology 10, 203-213 (2009)
  doi:10.1038/ni.1692.