November 2009
Protein trafficking: Glycan structure sorts it out
A mutant cell line deficient in the transport of GPI-linked proteins initiates the discovery of an unknown phosphodiesterase as critical for GPI maturation and sorting.
Original research paper: Cell 139, 352-365 (2009)
doi:10.1016/j.cell.2009.08.040Cell migration: Cadherin glycans branch out
N-cadherin is N-glycosylated in three sites, with glycan branching regulating receptor dimerization, stability of cell–cell contacts and cell motility.
Original research paper: J. Biol. Chem. (Published online 21 October 2009)
doi:10.1074/jbc.M109.060806