Welcome to the November Functional Glycomics Update, your one-stop resource for news, highlights and research on glycobiology.
A mutant cell line deficient in the transport of GPI-linked proteins initiates the discovery of an unknown phosphodiesterase as critical for GPI maturation and sorting.
Original research paper: Cell 139, 352-365 (2009)
N-cadherin is N-glycosylated in three sites, with glycan branching regulating receptor dimerization, stability of cell–cell contacts and cell motility.
Original research paper: Journal of Biological Chemistry (21 October 2009)
Sugar modifications specifically target an antigen to C-type lectins expressed by dendritic cells, promoting its presentation to T cells and boosting the immune response.
Functional Glycomics Gateway (12 November 2009)
Trimming N-linked oligosaccharides on a viral coat protein affects the specificity and affinity of receptor binding, and might be an effective strategy for vaccine design.
Functional Glycomics Gateway (12 November 2009)
Journal of Proteome Research
Proceedings of the National Academy of Sciences
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