View source for Macrophage galactose lectin (MGL)

MGL is the best studied of the multiple C-type lectins on macrophages. It is also representative of the subclass of C-type lectins that bind galactose-related sugars.

== CFG Participating Investigators contributing to the understanding of this paradigm ==
In addition to creating the knockout for the two mouse forms of MGL, PIs have been involved in extensive studies of binding specificity and mechanism of ligand binding as well as the role of the receptor in macrophage signaling.
* PIs working on MGL include: Nicolai Bovin, Kurt Drickamer, Toshisuke Kawasaki, Cheng Liu, Yvette van Kooyk, Hui Wu
* Non-PIs with who have used CFG resources to study MGL include: Siamon Gordon, Alan Saltiel
* PIs working on MGL-related glycan-binding proteins (GBPs), particularly Mincle, include: Anthony dApice, Joshua Fierer, Rikard Holmdahl, Christopher O'Callaghan, Judy Teale, Christine Wells
* Non-PIs with who have used resources to study related members of this paradigm group include: Roland Lang, Ulrich Maus, Gunnar Nilsson, Kenneth Rock

== Progress toward understanding this GBP paradigm ==

=== Carbohydrate ligands ===

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=== Cellular expression ===

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=== Structure ===

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=== Biological roles of GBP-ligand interaction ===

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== CFG resources used in investigations ==
The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=MGL&maxresults=20 CFG database search results for MGL].

=== Glycan profiling ===

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=== Glycogene microarray ===

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=== Knockout mouse lines ===
Knockouts for one of the mouse orthologs of MGL was distributed by the CFG and the [https://www.functionalglycomics.org/glycomics/publicdata/phenotyping.jsp phenotype] was analyzed.

=== Glycan array ===
The glycan-binding specificity of human and mouse versions of MGL have been analyzed by glycan array screening.

== Related GBPs ==
Other C-type lectins on macrophages include the mannose receptor, mincle, macrophage C- type lectin (MCL), and dectin-1.

== References ==
<references/>
* Singh SK, Streng-Ouwehand I, Litjens M, Weelij DR, Garca-Vallejo JJ, van Vliet SJ, Saeland E, van Kooyk Y (2009) Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties. Mol Immunol 46, 1240-1249.
* Westcott DJ, Delproposto JB, Geletka LM, Wang T, Singer K, Saltiel AR, Lumeng CN (2009) MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med 206, 3143-56.
* van Vliet SJ, van Liempt E, Saeland E, Aarnoudse CA, Appelmelk B, Irimura T, Geijtenbeek TBH, Blixt O, Alvarez R, van Die I, van Kooyk Y (2005) Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. Int Immunol 17, 661-669.
* Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, Beckhouse AG, Lo YL, Manzanero S, Cobbold C, Schroder K, Ma B, Orr S, Stewart L, Lebus D, Sobieszczuk P, Hume DA, Stow J, Blanchard H, Ashman RB (2008) The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol 180, 7404-7413.

== Acknowledgements ==
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk