Ficolins/Mannose-binding protein - Revision history

Nicole Thielens: /* Biosynthesis of ligands */

2011-04-04T11:50:06Z

Biosynthesis of ligands

Carole Weaver: /* Knockout mouse lines */

2011-03-31T22:08:39Z

Knockout mouse lines

Carole Weaver: /* Glycogene microarray */

2011-03-25T23:47:09Z

Glycogene microarray

Nicole Thielens: /* Biosynthesis of ligands */

2011-03-25T07:51:16Z

Biosynthesis of ligands

Nicole Thielens: /* Biosynthesis of ligands */

2011-03-25T07:50:06Z

Biosynthesis of ligands

Nicole Thielens: /* Biosynthesis of ligands */

2011-03-25T07:49:47Z

Biosynthesis of ligands

Nicole Thielens: /* Biosynthesis of ligands */

2011-03-25T07:49:04Z

Biosynthesis of ligands

Nicole Thielens: /* Biosynthesis of ligands */

2011-03-25T07:47:23Z

Biosynthesis of ligands

Nicole Thielens: /* Biosynthesis of ligands */

2011-03-25T07:45:38Z

Biosynthesis of ligands

Nicole Thielens: /* Biosynthesis of ligands */

2011-03-25T07:35:32Z

Biosynthesis of ligands

@@ Line 34: / Line 34: @@
 <br><br>
 <b>Glycans on fungi</b><br>
-The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. The linear polymer is synthesized from UDP-glucose (UDGG) by the multisubunit enzyme UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. This enzymatic complex contains two catalytic and one regulatory subunits that were first identified in "S. cerevisiae".<ref>Douglas CM, Foor F, Marrinan JA, Morin N, Nielsen JB, Dahl AM, Mazur P, Baginsky W, Li W, el-Sherbeini M, Clemas JA, Mandala SM, Frommer BR, Kurz MB (1994) The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. Proc Natl Acad Sci U S A 91:12907-11</ref><ref>Mazur P, Morin N, Baginsky W, el-Sherbeini M, Clemas JA, Nielsen JB, Foor F. (1995) Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol. 15:5671-81</ref><ref>Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, Zheng Y, Watanabe T, Levin DE, Ohya Y (1996) Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science 272:279-81</ref>
+The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. The linear polymer is synthesized from UDP-glucose (UDGG) by the multisubunit enzyme UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. This enzymatic complex contains two catalytic and one regulatory subunits that were first identified in ''Saccharomyces cerevisiae''.<ref>Douglas CM, Foor F, Marrinan JA, Morin N, Nielsen JB, Dahl AM, Mazur P, Baginsky W, Li W, el-Sherbeini M, Clemas JA, Mandala SM, Frommer BR, Kurz MB (1994) The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. Proc Natl Acad Sci U S A 91:12907-11</ref><ref>Mazur P, Morin N, Baginsky W, el-Sherbeini M, Clemas JA, Nielsen JB, Foor F. (1995) Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol. 15:5671-81</ref><ref>Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, Zheng Y, Watanabe T, Levin DE, Ohya Y (1996) Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science 272:279-81</ref>
 === Structure ===

@@ Line 58: / Line 58: @@
 === Knockout mouse lines ===
 === Glycan array ===
 The binding specificities of several of the ficolins have been analyzed and other members of the group were screened on the CFG glycan array.

← Older revision		Revision as of 23:47, 25 March 2011
Line 54:		Line 54:

	=== Glycogene microarray ===		=== Glycogene microarray ===
		+	Probes for mouse and human MBP have been included in all versions of the CFG glycogene chip.
		+	<br>

−	~~<br>~~
	=== Knockout mouse lines ===		=== Knockout mouse lines ===

@@ Line 34: / Line 34: @@
 <br><br>
 <b>Glycans on fungi</b><br>
-The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. The linear polymer is synthesized from UDP-glucose (UDGG) by the multisubunit enzyme UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. This enzymatic complex contains two catalytic and one regulatory subunits that werefirst identified in "S. cerevisiae".<ref>Douglas CM, Foor F, Marrinan JA, Morin N, Nielsen JB, Dahl AM, Mazur P, Baginsky W, Li W, el-Sherbeini M, Clemas JA, Mandala SM, Frommer BR, Kurz MB (1994) The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. Proc Natl Acad Sci U S A 91:12907-11</ref><ref>Mazur P, Morin N, Baginsky W, el-Sherbeini M, Clemas JA, Nielsen JB, Foor F. (1995) Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol. 15:5671-81</ref><ref>Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, Zheng Y, Watanabe T, Levin DE, Ohya Y (1996) Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science 272:279-81</ref>
+The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. The linear polymer is synthesized from UDP-glucose (UDGG) by the multisubunit enzyme UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. This enzymatic complex contains two catalytic and one regulatory subunits that were first identified in "S. cerevisiae".<ref>Douglas CM, Foor F, Marrinan JA, Morin N, Nielsen JB, Dahl AM, Mazur P, Baginsky W, Li W, el-Sherbeini M, Clemas JA, Mandala SM, Frommer BR, Kurz MB (1994) The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. Proc Natl Acad Sci U S A 91:12907-11</ref><ref>Mazur P, Morin N, Baginsky W, el-Sherbeini M, Clemas JA, Nielsen JB, Foor F. (1995) Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol. 15:5671-81</ref><ref>Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, Zheng Y, Watanabe T, Levin DE, Ohya Y (1996) Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science 272:279-81</ref>
 === Structure ===

@@ Line 28: / Line 28: @@
 === Biosynthesis of ligands ===
 <b>Glycans on viruses</b><br>
-High mannose oligosaccharides on viral envelope proteins that are ligands for mannose-*binding protein result from incomplete processing of glycans in the pathway for biosynthesis of complex N-linked glycans ([http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/geMolecule.jsp?slideNumber=default GT Database]).
+High mannose oligosaccharides on viral envelope proteins that are ligands for mannose-binding protein result from incomplete processing of glycans in the pathway for biosynthesis of complex N-linked glycans ([http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/geMolecule.jsp?slideNumber=default GT Database]).
 <br><br>
 <b>Glycans on bacteria</b><br>

@@ Line 27: / Line 27: @@
 === Biosynthesis of ligands ===
-<br>The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. The linear polymer is synthesized from UDP-glucose (UDGG) by the multisubunit enzyme UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. This enzymatic complex contains two catalytic and one regulatory subunits that werefirst identified in "S. cerevisiae".
+<br>The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. The linear polymer is synthesized from UDP-glucose (UDGG) by the multisubunit enzyme UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. This enzymatic complex contains two catalytic and one regulatory subunits that werefirst identified in "S. cerevisiae".<ref>Douglas CM, Foor F, Marrinan JA, Morin N, Nielsen JB, Dahl AM, Mazur P, Baginsky W, Li W, el-Sherbeini M, Clemas JA, Mandala SM, Frommer BR, Kurz MB (1994) The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. Proc Natl Acad Sci U S A 91:12907-11</ref><ref>Mazur P, Morin N, Baginsky W, el-Sherbeini M, Clemas JA, Nielsen JB, Foor F. (1995) Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol. 15:5671-81</ref><ref>Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, Zheng Y, Watanabe T, Levin DE, Ohya Y (1996) Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science 272:279-81</ref>
 === Structure ===