Macrophage galactose lectin (MGL) - Revision history

Kurt Drickamer: /* Knockout mouse lines */

2011-04-16T09:02:54Z

Knockout mouse lines

Kurt Drickamer: /* Carbohydrate ligands */

2011-04-15T07:48:36Z

Carbohydrate ligands

Kurt Drickamer: /* Carbohydrate ligands */

2011-04-15T07:48:18Z

Carbohydrate ligands

Kurt Drickamer: /* Biosynthesis of ligands */

2011-04-15T07:47:44Z

Biosynthesis of ligands

Joy Burchell: /* Biosynthesis of ligands */

2011-03-28T12:59:12Z

Biosynthesis of ligands

Joy Burchell: /* Cellular expression of GBP and ligands */

2011-03-28T12:50:50Z

Cellular expression of GBP and ligands

Joy Burchell: /* Carbohydrate ligands */

2011-03-28T12:45:47Z

Carbohydrate ligands

Carole Weaver: /* Related GBPs */

2011-03-18T21:50:54Z

Related GBPs

Carole Weaver at 21:34, 18 March 2011

2011-03-18T21:34:17Z

Kurt Drickamer: Undo revision 1434 by Kurt Drickamer (Talk)

2011-03-17T18:29:06Z

Undo revision 1434 by Kurt Drickamer (Talk)

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 === Knockout mouse lines ===
-Knockouts for one of the mouse orthologs of MGL were distributed by the CFG and the [https://www.functionalglycomics.org/glycomics/publicdata/phenotyping.jsp phenotype] was analyzed.
+Mice lacking MGL-1<ref name=Onami2002>Onami, TM, Lin, M-Y, Page, DM, Shirley A. Reynolds, SA, Katayama, CD, Marth, JD, Irimura, T, Varki, A, Varki, N and Hedrick SM (2002) Generation of mice deficient for dacrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol. Cell. Biol. 22, 5173-5181</ref> were distributed by the CFG and the [https://www.functionalglycomics.org/glycomics/publicdata/phenotyping.jsp phenotype] was analyzed. Mice lacking  MGL-2 have also been described.<ref name="Denda2010">Denda-Nagai, K, Aida, S, Saba, K, Suzuki, K, Moriyama, S, Oo-puthinan, S, Tsuiji, M, Morikawa, A, Kumamoto, Y, Sugiura, D, Kudo, A, Akimoto, Y, Kawakami, H, Bovin NV, and Irimura, T (2010) Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. J. Biol. Chem. 285, 19193–19204</ref> ES cells for an MGL-1/2 double knockout, generated in Core F, are available from  [http://www.functionalglycomics.org/static/consortium/resources/resourcecoref.shtml#table1 MMRRC].
 === Glycan array ===

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 *hMGL binds terminal α- and β-linked GalNAc residues on glycoproteins, glycolipids and bacterial LPS, including Tn antigen and GalNAcβ1-4GlcNAc-R (LDN) antigens <ref name="Suzuki 1996"/><ref name="Van Vliet 2005">van Vliet SJ, van Liempt E, Saeland E, Aarnoudse CA, Appelmelk B, Irimura T, Geijtenbeek TB, Blixt O, Alvarez R, van Die I and van Kooyk Y. 2005. Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. Int Immunol. 17:661-669</ref><ref>van Sorge NM, Bleumink NM, van Vliet SJ, Saeland E, van der Pol WL, van Kooyk Y and van Putten JP. 2009. N-glycosylated proteins and distinct lipooligosaccharide glycoforms of Campylobacter jejuni target the human C-type lectin receptor MGL. Cell Microbiol. 11:1768-1781</ref><ref>Saeland E, van Vliet SJ, Backstrom M, van den Berg VC, Geijtenbeek TB, Meijer GA and van Kooyk Y. 2007. The C-type lectin mgl expressed by dendritic cells detects glycan changes on Muc1 in colon carcinoma. Cancer Immunol Immunother. 56:1225-1236</ref><ref name="Napoletano2007">Napoletano C, Rughetti A, Tarp M.P.A, Coleman J Bennett,E.P, Picco G, Sale P, Denda-Hagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M. Tumour associated Tn-MUC1 glycoform is internalised througfh the macrophage galactose C-type lectin and delivered to the HLA class I and Class II compartments in dendritic cells. Cancer Research, 2007, 67(17): 8358-8367</ref>.
 *hMGL can also bind to STn when presented on a peptide or polyacrylamide backbone.
 === Cellular expression of GBP and ligands ===

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 *mMGL1 binds Lewis X and Lewis A structures, whereas mMGL2 recognizes N-acetylgalactosamine (GalNAc) and galactose, including the O-linked Tn-antigen and TF-antigen <ref name=Tsuiji 2002"/><ref name="Singh 2009"/><Ref name="Napoletano2007"/>
 *hMGL binds terminal α- and β-linked GalNAc residues on glycoproteins, glycolipids and bacterial LPS, including Tn antigen and GalNAcβ1-4GlcNAc-R (LDN) antigens <ref name="Suzuki 1996"/><ref name="Van Vliet 2005">van Vliet SJ, van Liempt E, Saeland E, Aarnoudse CA, Appelmelk B, Irimura T, Geijtenbeek TB, Blixt O, Alvarez R, van Die I and van Kooyk Y. 2005. Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. Int Immunol. 17:661-669</ref><ref>van Sorge NM, Bleumink NM, van Vliet SJ, Saeland E, van der Pol WL, van Kooyk Y and van Putten JP. 2009. N-glycosylated proteins and distinct lipooligosaccharide glycoforms of Campylobacter jejuni target the human C-type lectin receptor MGL. Cell Microbiol. 11:1768-1781</ref><ref>Saeland E, van Vliet SJ, Backstrom M, van den Berg VC, Geijtenbeek TB, Meijer GA and van Kooyk Y. 2007. The C-type lectin mgl expressed by dendritic cells detects glycan changes on Muc1 in colon carcinoma. Cancer Immunol Immunother. 56:1225-1236</ref><ref name="Napoletano2007">Napoletano C, Rughetti A, Tarp M.P.A, Coleman J Bennett,E.P, Picco G, Sale P, Denda-Hagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M. Tumour associated Tn-MUC1 glycoform is internalised througfh the macrophage galactose C-type lectin and delivered to the HLA class I and Class II compartments in dendritic cells. Cancer Research, 2007, 67(17): 8358-8367</ref>.
 <br>
 === Cellular expression of GBP and ligands ===

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 === Biosynthesis of ligands ===
 <br>
 === Structure ===

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 === Biosynthesis of ligands ===
 <br>
 === Structure ===
 [[image:MGL.jpg]]<br>

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 MGL is expressed on dendritic cells and macrophages. <ref name="Higashi 2002"/><ref name=" van Vliet SJ1200 ">van Vliet SJ, Gringhuis SI, Geijtenbeek TB and van Kooyk Y. 2006. Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45. Nat Immunol. 7:1200-1208</ref>
 <br>
 === Biosynthesis of ligands ===

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 == Related GBPs ==
-Other C-type lectins on macrophages include the mannose receptor, mincle <ref>Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, Beckhouse AG, Lo YL, Manzanero S, Cobbold C, Schroder K, Ma B, Orr S, Stewart L, Lebus D, Sobieszczuk P, Hume DA, Stow J, Blanchard H, Ashman RB. 2008. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol 180: 7404-7413</ref>, macrophage C- type lectin (MCL), and dectin-1.
+Other C-type lectins on macrophages include the mannose receptor [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=DC-SIGNR&maxresults=20 (CFG data)], mincle <ref>Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, Beckhouse AG, Lo YL, Manzanero S, Cobbold C, Schroder K, Ma B, Orr S, Stewart L, Lebus D, Sobieszczuk P, Hume DA, Stow J, Blanchard H, Ashman RB. 2008. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol 180: 7404-7413</ref> [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=mincle&maxresults=20 (CFG data)], macrophage C- type lectin (MCL) [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=MCL&maxresults=20 (CFG data)], and dectin-1 [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=dectin-1&maxresults=20 (CFG data)].
 == References ==

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 === Glycan array ===
-The glycan-binding specificity of [http://www.functionalglycomics.org/glycomics/HServlet?operation=view&sideMenu=no&psId=primscreen_GLYCAN_v2_13_11262003 human] and [http://www.functionalglycomics.org/glycomics/HServlet?operation=view&sideMenu=no&psId=primscreen_2010 mouse] versions of MGL  have been analyzed by glycan array screening <ref name="Van Vliet 2005"/><ref name="Singh 2009"/>. See all glycan array results for MGL [http://www.functionalglycomics.org/glycomics/search/jsp/result.jsp?query=mgl&cat=coreh here].
+The glycan-binding specificity of [http://www.functionalglycomics.org/glycomics/HServlet?operation=view&sideMenu=no&psId=primscreen_GLYCAN_v2_13_11262003 human] and [http://www.functionalglycomics.org/glycomics/HServlet?operation=view&sideMenu=no&psId=primscreen_2010 mouse] versions of MGL  have been analyzed by glycan array screening <ref name="Van Vliet 2005"/><ref name="Singh 2009"/>. See all glycan array results for MGL [http://www.functionalglycomics.org/glycomics/search/jsp/result.jsp?query=mgl&cat=coreh here]. See glycan array results for these related GBPs: [http://www.functionalglycomics.org/glycomics/search/jsp/result.jsp?query=mannose%20AND%20receptor%20NOT%20asialoglycoprotein&cat=coreh mannose receptor,] [http://www.functionalglycomics.org/glycomics/search/jsp/result.jsp?query=mincle&cat=coreh mincle,] [http://www.functionalglycomics.org/glycomics/search/jsp/result.jsp?query=MCL&cat=coreh macrophage C-type lectin (MCL),] and [http://www.functionalglycomics.org/glycomics/search/jsp/result.jsp?query=dectin-1&cat=coreh dectin-1.]
 == Related GBPs ==