Difference between revisions of "DC-SIGN"
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== CFG resources used in investigations == | == CFG resources used in investigations == | ||
| − | + | The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=DC-SIGN&maxresults=20 CFG database search results for DC-SIGN]. | |
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=== Glycan profiling === | === Glycan profiling === | ||
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=== Knockout mouse lines === | === Knockout mouse lines === | ||
| − | Knockout mice for three potential DC-SIGN orthologues were created by the CFG and distributed to PIs, and their phenotypes were analyzed. | + | Knockout mice for three potential DC-SIGN orthologues ([https://www.functionalglycomics.org/static/consortium/resources/DataCoreFdc.shtml DC-SIGN], [https://www.functionalglycomics.org/static/consortium/resources/DataCoreFCG.shtml LSECtin-total knockout], and [https://www.functionalglycomics.org/static/consortium/resources/DataCoreFCG.shtml LSECtin-conditional knockout]) were created by the CFG and distributed to PIs, and their [http://www.functionalglycomics.org/glycomics/publicdata/phenotyping.jsp phenotypes] were analyzed. |
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=== Glycan array === | === Glycan array === | ||
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Glycan array analysis and synthetic oligosaccharides were used to elucidate DC-SIGN glycan-binding specificity and analyze the mechanism of specific glycan binding. | Glycan array analysis and synthetic oligosaccharides were used to elucidate DC-SIGN glycan-binding specificity and analyze the mechanism of specific glycan binding. | ||
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== Related GBPs == | == Related GBPs == | ||
Revision as of 23:31, 1 April 2010
DC-SIGN is a C-type lectin that plays roles in both cell-cell and host-pathogen interactions, and thus serves as a model for both processes. This glycan-binding protein (GBP) paradigm also serves as a model for other members of the C-type lectin family expressed on dendritic cells.
CFG Participating Investigators contributing to the understanding of this paradigm
Many investigators, both CFG Participating Investigators (PIs) and non-PIs using CFG resources, have led extensive studies on DC-SIGN, particularly regarding structure-function relationships, interactions with pathogens, and signaling functions in dendritic cells.
PIs:
- Pedro Bonay
- Angel Corbi
- Kurt Drickamer
- Juan Garcia-Vallejo
- Donald Harn
- Kayo Inaba
- Benhur Lee
- Olivier Neyrolles
- Irma van Die
- Yvette van Kooyk
- William Weis
- Martin Wild
Non-PIs with who have used CFG resources:
- Brigitte Gicquel
- Arne Skerra
- Ralph Steinman
Progress toward understanding this GBP paradigm
Carbohydrate ligands
Cellular expression
Structure
Biological roles of GBP-ligand interaction
CFG resources used in investigations
The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for DC-SIGN.
Glycan profiling
Glycogene microarray
Knockout mouse lines
Knockout mice for three potential DC-SIGN orthologues (DC-SIGN, LSECtin-total knockout, and LSECtin-conditional knockout) were created by the CFG and distributed to PIs, and their phenotypes were analyzed.
Glycan array
Glycan array analysis and synthetic oligosaccharides were used to elucidate DC-SIGN glycan-binding specificity and analyze the mechanism of specific glycan binding.
Related GBPs
Other dendritic cell lectins include langerin, DCIR, and DCAR. Paralogs on other cells include DC-SIGNR.
References
Acknowledgements
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk
