Difference between revisions of "Mannose receptor"
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== Progress toward understanding this GBP paradigm == | == Progress toward understanding this GBP paradigm == | ||
| − | + | As in the case of the selectins, much of the evidence for functions of the mannose receptor pre-dates the consortium. However, there have been some further developments for this receptor and other members of the group. PIs have generated and characterized knockout mice, defined the sugar-binding specificities, demonstrated clearance in vivo and endocytosis in tissue culture, and performed structural analysis. | |
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=== Carbohydrate ligands === | === Carbohydrate ligands === | ||
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== CFG resources used in investigations == | == CFG resources used in investigations == | ||
The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=%22mannose+receptor%22&maxresults=20 CFG database search results for "mannose receptor"]. | The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the [http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=%22mannose+receptor%22&maxresults=20 CFG database search results for "mannose receptor"]. | ||
Revision as of 16:39, 13 June 2010
The mannose receptor represents a paradigm for the involvement of C-type lectins in clearance of circulating glycoproteins. The role of glycan-binding receptors as tags for uptake and turnover was one of the first established functions for endogenous sugar-binding proteins and provides a key model for how glycans can modulate communication between cells in a physiological context. While the asialoglycoprotein receptor would be considered the founder member of this group of receptors, the in vivo evidence for its function is less compelling than the results for the mannose receptor, which has well defined roles in clearance of sulfated glycoprotein hormones and mannose-bearing glycoproteins released at sites of inflammation.
The mannose receptor represents a paradigm for the involvement of C-type lectins in clearance of circulating glycoproteins. The role of glycan-binding receptors as tags for uptake and turnover was one of the first established functions for endogenous sugar-binding proteins and provides a key model for how glycans can modulate communication between cells in a physiological context. While the asialoglycoprotein receptor would be considered the founder member of this group of receptors, the in vivo evidence for its function is less compelling than the results for the mannose receptor, which has well defined roles in clearance of sulfated glycoprotein hormones as well as mannose-bearing glycoproteins released at sites of inflammation[1].
In addition to the mannose receptor and the asialoglycoprotein receptor, the scavenger receptor C-type lectin may also be involved in clearance of serum glycoproteins. The asialoglycoprotein receptor and the scavenger receptor C-type lectin have different domain organisations and ligand binding specificities compared to the mannose receptor.
PIs working with the mannose receptor include: Ten Feizi; Reiko Lee; Yuan Lee; Michel Nussenzweig; Maureen Taylor; Kurt Drickamer; Chi-Huey Wong; Bill Weis; Pauline Rudd; Nathalie Scholler
Progress toward understanding this GBP paradigm
As in the case of the selectins, much of the evidence for functions of the mannose receptor pre-dates the consortium. However, there have been some further developments for this receptor and other members of the group. PIs have generated and characterized knockout mice, defined the sugar-binding specificities, demonstrated clearance in vivo and endocytosis in tissue culture, and performed structural analysis.
Carbohydrate ligands
Cellular expression
Structure
Biological roles of GBP-ligand interaction
CFG resources used in investigations
The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for "mannose receptor".
Glycan profiling
Glycogene microarray
The CFG analyzed patterns of mannose receptor expression.
Knockout mouse lines
Before funding for knockout mice was discontinued, the CFG developed the DNA construct to create a mouse line lacking the scavenger receptor. The construct can now be obtained from the Mutant Mouse Regional Resource Center (MMRRC) at the University of California, Davis.
Glycan array
The CFG analyzed the binding specificities of the mannose receptor.
Related GBPs
Asialoglycoprotein receptor, scavenger receptor C-type lectin, Kupffer cell receptor
References
- ↑ Taylor PR, Gordon S, Martinez-Pomares L (2005) The mannose receptor: linking homeostasis and immunity through sugar recognition. Trends Immunol 26,104-110
- Coombs PJ, Taylor ME, Drickamer K (2006) Two categories of mammalian galactose-binding receptors distinguished by glycan array profiling. Glycobiology 16, 1C-7C.
- Feinberg H, Taylor ME, Weis WI (2007) Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis x by a novel mechanism. J Biol Chem 282, 17250-17258.
- Coombs PJ, Graham SA, Drickamer K, Taylor ME (2005) Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands. J Biol Chem 280, 22993-22999.
Acknowledgements
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Maureen Taylor, Yvette van Kooyk
