DC-SIGN

DC-SIGN is a C-type lectin that plays roles in both cell-cell and host-pathogen interactions, and thus serves as a model for both processes. This glycan-binding protein (GBP) paradigm also serves as a model for other members of the C-type lectin family expressed on dendritic cells.

CFG Participating Investigators contributing to the understanding of this paradigm

Many investigators, both CFG Participating Investigators (PIs) and non-PIs using CFG resources, have led extensive studies on DC-SIGN, particularly regarding structure-function relationships, interactions with pathogens, and signaling functions in dendritic cells.

PIs:

• Pedro Bonay
• Angel Corbi
• Kurt Drickamer
• Juan Garcia-Vallejo
• Donald Harn
• Kayo Inaba
• Benhur Lee
• Olivier Neyrolles
• Irma van Die
• Yvette van Kooyk
• William Weis
• Martin Wild

Non-PIs with who have used CFG resources:

• Brigitte Gicquel
• Arne Skerra
• Ralph Steinman

CFG resources used in investigations

The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for DC-SIGN.

Knockout mouse lines

Knockout mice for three potential DC-SIGN orthologues (DC-SIGN, LSECtin-total knockout, and LSECtin-conditional knockout) were created by the CFG and distributed to PIs, and their phenotypes were analyzed.

Glycan array

Glycan array analysis and synthetic oligosaccharides were used to elucidate DC-SIGN glycan-binding specificity and analyze the mechanism of specific glycan binding.

Related GBPs

Other dendritic cell lectins include langerin, DCIR, and DCAR. Paralogs on other cells include DC-SIGNR.

Acknowledgements

The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk