Macrophage galactose lectin (MGL)
MGL is the best studied of the multiple C-type lectins on macrophages. It is also representative of the subclass of C-type lectins that bind galactose-related sugars.
CFG Participating Investigators contributing to the understanding of this paradigm
In addition to creating the knockout for the two mouse forms of MGL, PIs have been involved in extensive studies of binding specificity and mechanism of ligand binding as well as the role of the receptor in macrophage signaling.
- PIs working on MGL include: Nicolai Bovin, Kurt Drickamer, Toshisuke Kawasaki, Cheng Liu, Yvette van Kooyk, Hui Wu
- Non-PIs with who have used CFG resources to study MGL include: Siamon Gordon, Alan Saltiel
- PIs working on MGL-related glycan-binding proteins (GBPs), particularly Mincle, include: Anthony dApice, Joshua Fierer, Rikard Holmdahl, Christopher O'Callaghan, Judy Teale, Christine Wells
- Non-PIs with who have used resources to study related members of this paradigm group include: Roland Lang, Ulrich Maus, Gunnar Nilsson, Kenneth Rock
Progress toward understanding this GBP paradigm
Carbohydrate ligands
Cellular expression
Structure
Biological roles of GBP-ligand interaction
CFG resources used in investigations
The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for MGL.
Glycan profiling
Glycogene microarray
Knockout mouse lines
Knockouts for one of the mouse orthologs of MGL was distributed by the CFG and the phenotype was analyzed.
Glycan array
The glycan-binding specificity of human and mouse versions of MGL have been analyzed by glycan array screening.
Related GBPs
Other C-type lectins on macrophages include the mannose receptor, mincle, macrophage C- type lectin (MCL), and dectin-1.
References
Acknowledgements
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk
