LSECtin
LSECtin serves a model for other members of the C-type lectin family that are expressed on sinusoidal endothelial cells and facilitate viral infection, but lack endocytic function.
CFG Participating Investigators contributing to the understanding of this paradigm
Several PIs are working on ligand-binding specificity of LSECtin and interaction of this C-type lectin with viral pathogens.
- PIs working on LSECtin include: Angel Corbi, Kurt Drickamer, Maureen Taylor
- PIs working on L-SIGN/DC-SIGNR include: Ben Appelmelk, Angel Corbi, Kurt Drickamer, Benhur Lee, Maureen Taylor, Yvette van Kooyk, Bill Weis
Progress toward understanding this GBP paradigm
Carbohydrate ligands
Cellular expression
Structure
Biological roles of GBP-ligand interaction
CFG resources used in investigations
The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for LSECtin.
Glycan profiling
Glycogene microarray
Knockout mouse lines
LSECtin knockout mice were created by the CFG (LSECtin-total knockout and LSECtin-conditional knockout) and are in the queue for phenotype analysis in 2010/11.
Glycan array
Glycan array analysis of LSECtin has revealed unusually high selectivity for specific ligands.
Related GBPs
L-SIGN / DC-SIGNR
References
Powlesland AS, Fisch T, Taylor ME, Smith DF, Tissot B, Dell A, Phölmann S, Drickamer K (2008) A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans. J Biol Chem 283,/b>, 593-602.
Acknowledgements
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk
