July 2011

• N-linked glycosylation: A reaction takes shape

  A 3.4-Å structure of the Campylobacter lari oligosaccharyltransferase provides the first detailed view of protein structure, substrate binding and asparagine activation in the most common modification reaction in glycobiology.

  Original research paper: Nature 474, 350-355 (2011)

• Ushering perforin

  Recent work reveals how cytotoxic lymphocytes ensure that a pore-forming glycoprotein gets to its storage site without causing cellular damage.

  Original research paper: Immunity 34, 879-892 (2011)