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MOUSE LINES


Knockout Lines Being Transferred


The knockout strains acquired from Participating Investigators that have been available through Core F are in transition to new homes. When the transition is complete, some strains will be available from The Jackson Laboratories and some will continue to be available from the original contributors.

The first table lists strains that are being transferred to The Jackson Laboratories. During the transition phase they will continue to be available from Core F. Please contact the Director of Core F, Dr. Bo Ma, if you are interested in obtaining any of these strains. He will let you know the strain’s status.

The second table lists strains that are now available from the original contributor. Contact information is provided in the second column, where clicking on the investigator's name will open an e-mail to the individual.

Knockout Lines Being Transferred to The Jackson Laboratories (sorted by Gene Family)

Original Publication Name Colony Code Name1 Gene Symbol2 Gene Family
Name of Enzyme or Protein
Available at JAX
mMGL MM Mgl1 GBP: C-type Macrophage galactose- and N-acetylgalactosamine-specific C-type lectin Yes
PSGL-1 PS Selplg GBP: C-type Selectin, platelet (p-selectin) ligand Yes
Gal-1 and Gal-3 GN Lgals1 and Lgals3 GBP: Galectin Galectin-1 and Galectin-3 (double KO) Yes
mSiglec-2 CD Cd22 GBP: Siglec CD22 antigen Yes
Siglec-3 CC Cd33 GBP: Siglec Sialic acid-binding Ig superfamily lectin 3 Yes
FUT1 FD Fut1 GT: Fuc a1-2fucosyltransferase-I Yes
FUT2 FE Fut2 GT: Fuc a1-2fucosyltransferase-II Yes
b1,4GalT1 BG3 B4galt1 GT: Gal UDP-Gal:bGlcNAcb1-4galactosyltransferase, polypeptide 1 Yes
b1,4GalT1 BT4 B4galt1 GT: Gal UDP-Gal:bGlcNAcb1-4galactosyltransferase, polypeptide 1 Yes
Mgat5 MG5 Mgat5 GT: GlcNAc b1-6N-acetylglucosaminyltransferase-V Yes
C6ST CS Chst3 GT: Sulfo Carbohydrate (condroitin 6/keratan) sulfotransferase 3 Yes

1 CFG internal mouse line identifier, specific and unique for each construct, background and type of mutation

2 As per the Mouse Genomic Nomenclature Committee (MGNC) maintained by Mouse Genome Informatics (MGI) of The Jackson Laboratory

3 First ATG mutated, only long message ablated

4 Total gene ablation, homozygous neonatal lethal

5 Only heterozygous mice are currently available.



Knockout Lines Available From Contributing Investigators (sorted by Gene Family)

Original Publication Name Available From Colony Code Name1 Gene Symbol2 Gene Family
Name of Enzyme or Protein
Gal-3 Fu-Tong Liu GC Lgals3 GBP: Galectin Galectin-3
FucT-IV John Lowe FA Fut4 GT: Fuc a1-3fucosyltransferase-IV
FucT-VII John Lowe FB Fut7 GT: Fuc a1-3fucosyltransferase-VII
FucT-IV and FucT-VII John Lowe FC Fut4 and Fut7 GT: Fuc a1-3fucosyltransferase-IV and a1-3fucosyltransferase-VII (double KO)
GalNAcT Sda blood group John Lowe GW B4galnt2 GT: GalNAc N-acetylneuraminyl-galactosyl-N-acetylglucosaminylpolypeptide-b1-4N-AcGalT
C2 GlcNAcT Jamey Marth CR Gcnt1 GT: GlcNAc Core 2 b1-6N-acetylglucosaminyltransfersase-I
Mgat3 Jamey Marth MT Mgat3 GT: GlcNAc Mannoside acetyl glucosaminyltransferase 3
ST3Gal-II Jamey Marth SP St3gal2 GT: Sia Sialyltransferase 5
ST3Gal-I Jamey Marth ST St3gal1 GT: Sia b-galactosidase a2-3sialyltransferase
ST3Gal-IV Jamey Marth SU St3gal4 GT: Sia b-galactosidase a2-3sialyltransferase
ST6Gal-I Jamey Marth SG St6gal1 GT: Sia N-acetyllactosaminide a2-6sialyltransferase

1 CFG internal mouse line identifier, specific and unique for each construct, background and type of mutation

2 As per the Mouse Genomic Nomenclature Committee (MGNC) maintained by Mouse Genome Informatics (MGI) of The Jackson Laboratory


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Novel Strains Generated by Core F

Timeline for Generating Mouse Lines

Novel strains available from MMRRC

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