October 2009
Stopping HIV: Glycopeptide opens the envelope
A new glycoconjugate, linking a CD4-mimetic peptide with a heparan sulfate oligosaccharide, binds cooperatively to the HIV envelope and neutralizes three virus strains.
Original research paper: Nat. Chem. Bio. 5, 743-748 (2009)
doi:10.1038/nchembio.207Wound healing: Integrin glycans galectin going
Galectin-3 cross-links complex N-glycans on α3β1 integrins to cluster the molecules, activate signaling and promote lamellipodia formation in epithelial wound healing.
Original research paper: J. Cell Sci. (15 September 2009)
doi:10.1074/jbc.M800066200