MOUSE TRANSGENICS CORE (F)
Overview
This Core is in the process of generating 19 new mouse strains with deleted or altered genes coding for glycan-binding
proteins (GBPs) and glycosyltransferases. A table with
information on the timeline for generating these lines is posted on the website. As novel knockout
mouse strains become available they will be provided to the Mouse Phenotype Core (G) for
phenotype analysis and their availability will be posted on the website. This Core also
acquires and maintains existing knockout or transgenic mouse strains of interest to the
program. Breeding pairs of
available strains are sent
to investigators both within and outside of the Consortium upon approval by the
Steering Committee.
Specific Objectives
- Generate new knockout and knockin mice to ablate or alter the functions of selected GBP
and glycosyltransferase genes
- Acquire and maintain existing knockout or transgenic strains of interest to the
program
- Implement 'speed genomics' for accelerated backcrossing of the genetic trait into a fixed
genetic background (C57BL/6)
- Direct and monitor breeding of mouse strains by The Scripps Research Institute custom
breeding program
- Supply mice to the Mouse Phenotype
Core (G) for phenotypic analysis
- Prepare mRNA from mouse tissues for the
Gene Micorarray Core (E)
- Distribute mice to investigators (upon Steering Committee approval)
Core F Team
- Jim Paulson and Jamey Marth, Coordinators
- Bo Ma, Director
- Joe Gassert, Administrative Assistant
- Anchang Hu, Colony Maintenance, Vector Construction, and Genetic Analysis
- Hua Tian, Colony Maintenance, Vector Construction, and Genetic Analysis
- Bo Ma, Vector Construction and Genetic Analysis
- Beth Ford, Director, TSRI Animal Services
- Sergey Kupriyanov, Director, TSRI Mouse Genetics Core
- Phil Ordoukhanian, Director, TSRI Nucleic Acids Core
- Greg Martin, Research Assistant, TSRI Mouse Genetics Core
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