Scientific Cores

SCIENTIFIC CORES: MAJOR ROLES, RESULTS AND PROGRESS

The Consortium is made up of one Administrative and seven Scientific Cores. The Scientific Cores are generating key material resources, unique tools and novel program information, and providing technical capabilities that are required to achieve the Specific Aims of the Consortium. In addition, several Cores are conducting research to provide a platform of information for use by scientific investigators and the other Cores. A summary of the major roles of each Scientific Core, as well as of the results and progress achieved to date, is provided in the table below.

Major Roles and Results and Progress of the Scientific Cores
Scientific Core (click on Core for more information)	Major Roles	Results and Progress (click on item for more information)
Bioinformatics Core (B)	Create databases for all program information Create special databases	Glycan-binding Protein Database Glycan Structures Database
Analytical Glycotechnology Core (C)	Profile glycan structures on mouse and human tissues and cells Perform carbohydrate structure analysis on GBP ligands and cell lines	Glycan Profiling of Mouse and Human Tissues and Cells
Glycan Array Synthesis Core (D)	Produce library of carbohydrate compounds Produce modified carbohydrates for design of glycoarray Produce recombinant GBPs	Available Carbohydrate Compounds Available Glycan-binding Proteins Available Antibodies Resources Distributed
Gene Microarray Core (E)	Design and produce Glyco-gene chip Analyze mRNA samples from Participating Investigators for gene expression Isolate RNA and analyze gene expression in mouse tissue	Glyco-gene Chip Analysis Gene List Resource Requests Approved Glyco-gene Chip Data
Mouse Transgenics Core (F)	Create new gene knockout mouse strains missing GBP or GT genes Breed mice for distribution to Core G and Participating Investigators	Available Mouse Lines Expected Mouse Lines Timeline for Generating Mouse Lines Completed Vector Designs Mouse Lines Distributed
Mouse Phenotype Core (G)	Conduct phenotype analysis on existing and new knockout mouse strains missing GBP or GT genes	Mouse Line Phenotype Timeline Phenotype Analysis Results
Protein-Glycan Interaction Core (H)	Analyze the carbohydrate specificity of GBPs Develop glycan array format for high throughput screening of GBP specificity	Available Glycan Array Screening Resource Requests Approved Glycan Array Data
Abbreviation: GBP, glycan-binding protein

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